VA Class

Vocabulary_ID=32

The following describes the procedure to update the VA Class vocabulary (concepts, synonyms, relationships, ancestry) with the latest release of the source.

The load process is a complete refresh of data. All new vocabulary entieties will be added. All vocabulary entities that do not exist in the latest files set will be marked as deprecated.

1.1 Scripts Transfer

All scripts and files listed at the bottom of this page should be transferred to specially created directory (eg /data/VACLASS).

Script Name	Description
32_create_schema.sql	Create prestage-stage schema with tables and indexes
32_load_to_prestage.sh	Load RxNorm row-data
32_transform_row_concepts.sql	Convert and store in stage table concept_stage
32_load_concepts.sql	Load only new concepts into concept table, add invalid code information
32_transform_row_relations.sql	Convert and store in stage table concept_relationship_stage
32_load_relations.sql	Load only new relationships into relationship table, add invalid code information.

1.2 Download data from source

The most current international release is located at the following URL: http://www.nlm.nih.gov/research/umls/rxnorm/docs/rxnormfiles.html

Historical archives located at: http://www.nlm.nih.gov/research/umls/rxnorm/docs/rxnormarchive.html

Note: Make sure you perform updates in chronological order. So, if you want to process a January and April release, execute the below steps for January, and after successful completion, for April.

Download the latest release file (e.g. RxNorm_full_08062012.zip)
Transfer downloaded zip file to /data/VACLASS directory.

Zip file suffix contains release date (e.g. 08062012=06-Aug-2012)
Latest production zip file is ~131MB in size

Note: For the rest of the document we will be referring to current schema as VACLASS_20120806 you would have to adjust this entry to correspond to current release date file

1.3 Build Database Schema

All tables will be located in the schema VACLASS_<DateOfSourceFile> as following: VACLASS_20120131
The following steps will create a schema and will grant to a schema owner appropriate permissions.

In addition to the schema, it will create tables to load raw data: RXNATOMARCHIVE,RXNCONSO,RXNCUI,RXNCUICHANGES,RXNDOC,RXNREL,RXNSAB,RXNSAT and RXNSTY as well as staging tables:

CONCEPT_STAGE,

CONCEPT_ANCESTOR_STAGE,

CONCEPT_RELATIONSHIP_STAGE,
SOURCE_TO_CONCEPT_MAP_STAGE

$ sqlplus System/<SystemPass>@DEV_VOCAB @32_create_schema.sql <VACLASS _Schema> <Pass_VACLASS _Schema>

Format of VACLASS _Schema should be VACLASS_YYYYMMDD (e.g. VACLASS_20120806 )

Staging tables match Vocabulary schema version 4.0 with slight modification. Modifications made to the tables are:

CONCEPT_STAGE.CONCEPT_ID is nullable

CONCEPT_RELATIONSHIP_STAGE

.REL_ID is nullable

1.4 Raw data load into Oracle tables

1.4.1 Extract files from the zip archive into the current directory

$ unzip -u RxNorm_full_08062012.zip -d rxnorm_20120806

1.4.2 Verify that the following 2 files have been created:

RXNCONSO.RRF (Latest file size ~96MB)

RXNATOMARCHIVE.RRF (Latest file size ~42MB)

RXNCUI.RRF (Latest file size ~1MB)

RXNCUICHANGES.RRF (Latest file size ~1MB)

RXNDOC.RRF (Latest file size ~1MB)

RXNREL.RRF (Latest file size ~230MB)

RXNSAB.RRF (Latest file size ~8KB)

RXNSAT.RRF (Latest file size ~385MB)

RXNSTY.RRF (Latest file size ~15MB)

1.4.4. Load raw data into Oracle.

      This sqlldr process will run for about 2min.
       $ ./32_load_to_prestage.sh /data/RxNorm/Arch/rxnorm_20120806 <VACLASS_Schema>/<Pass_VACLASS_Schema>
1.4.4.1 Verify that files with extension .bad are empty, no records have been rejected.

1.4.4.2 Copy data and intermediate files to backup area. In this step, downloaded files will be archived to preserve source of the data. Discuss a location of backup area with your system administrator.

       $ cp -Ru /data/VACLASS/*.zip /data/backup_area ; cp -Ru /data/VACLASS/*.log /data/backup_area
1.4.4.3 Verify that number of records loaded is equivalent to prior production load

$ sqlplus VA CLASS_20120806/myPass@DEV_VOCAB

Execute the following SQL commands:

SELECT count(*) FROM RXNCONSO;

Current production row count is: 979,203 Rows

SELECT count(*) FROM RXNREL;

Current production row count is: 3,485,382 Rows

1.5 Loading Staging Tables from raw

1.5.1 Convert and store in staging table concepts

Loaded from raw staged data RXNCONSO into the staged data CONCEPT_STAGE
In this step we will perform substitute GUID identifiers into numerical format.

$ sqlplus VACLASS_20120806/myPass@DEV_VOCAB @32_transform_row_concepts.sql

1.5.2 Verify that number of records loaded is equivalent to prior production load
In this step we will verify that number of active records in staging tables is valid prior to transfer data to historical DEV schema.

a. Number of Records in stage table

b. Number of records in DEV schema not deleted (active, prior load production)

c. How many records would be added to DEV schema table

d. How many active DEV records will be marked for deletion

In most cases number of records in stage (a) should be greater than number of active records in production (b)
In rare occasion that might not be the case. It is responsibility of the developer running the scripts to verify that that is the the valid.

$ sqlplus VACLASS_20120806/myPass@DEV_VOCAB

Execute the following SQL commands:

SELECT '- Num Rec in stage' AS scr, COUNT (8) cnt
FROM CONCEPT_STAGE c
WHERE C.VOCABULARY_ID = 32
UNION ALL
SELECT '- Num Rec in DEV not deleted' AS scr, COUNT (8) cnt
FROM DEV.CONCEPT d
WHERE d.VOCABULARY_ID = 32 AND NVL (d.INVALID_REASON, 'X') <> 'D'
UNION ALL
SELECT '- How many records would be new in DEV added' AS scr, COUNT (8) cnt
FROM CONCEPT_STAGE c
WHERE C.VOCABULARY_ID = 32
       AND NOT EXISTS
              (SELECT 1
                 FROM DEV.CONCEPT d
                WHERE d.VOCABULARY_ID = 32 AND c.CONCEPT_CODE = D.CONCEPT_CODE)
UNION ALL
SELECT '- How many DEV active will be marked for deletion' AS scr,
       COUNT (8) cnt
FROM DEV.CONCEPT d
WHERE     d.VOCABULARY_ID = 32
       AND NVL (d.INVALID_REASON, 'X') <> 'D'
       AND NOT EXISTS
              (SELECT 1
                 FROM CONCEPT_STAGE c
                WHERE c.VOCABULARY_ID = 32 AND c.CONCEPT_CODE = D.CONCEPT_CODE);

Current Result:
- Num Rec in stage 486
- Num Rec in DEV not deleted 486
- How many records would be new in DEV added 0
- How many DEV active will be marked for deletion 0

1.5.3 Load new concepts into DEV schema concept table,mark deprecated concepts as deleted. Valid start date, valid end date and invalid reason are left empty for now.
Transfer records from CONCEPT_STAGE to DEV.CONCEPT table

$ sqlplus VACLASS_20120806/myPass@DEV_VOCAB @32_load_concepts.sql

1.5.4 Load new concept relationships stage, identify invalid codes information

Loaded from the raw staged data RXNREL into the staged data CONCEPT_RELATIONSHIP_STAGE, identify invalid code information

$ sqlplus VACLASS_20120806/myPass@DEV_VOCAB @32_transform_row_relations.sql

1.5.5 Verify that number of records loaded is equivalent to prior production load

SELECT '- Num Rec in stage' AS scr, COUNT (8) cnt
FROM CONCEPT_RELATIONSHIP_STAGE c
UNION ALL
SELECT '- Num Rec in DEV not deleted' AS scr, COUNT (8) cnt
FROM DEV.CONCEPT_RELATIONSHIP d
WHERE EXISTS
(SELECT 1
FROM DEV.CONCEPT c
WHERE c.VOCABULARY_ID = 32 AND c.CONCEPT_ID = CONCEPT_ID_1)
AND EXISTS
(SELECT 1
FROM DEV.CONCEPT c
WHERE c.VOCABULARY_ID = 32 AND c.CONCEPT_ID = CONCEPT_ID_2)
AND NVL(d.INVALID_REASON, 'X') <> 'D'
UNION ALL
SELECT '- How many records would be new in DEV added' AS scr, COUNT (8) cnt
FROM CONCEPT_RELATIONSHIP_STAGE c
WHERE NOT EXISTS
(SELECT 1
FROM DEV.CONCEPT_RELATIONSHIP d
WHERE c.CONCEPT_ID_1 = d.CONCEPT_ID_1
AND c.CONCEPT_ID_2 = d.CONCEPT_ID_2
AND c.RELATIONSHIP_ID = d.RELATIONSHIP_ID)
UNION ALL
SELECT '- How many DEV active will be marked for deletion' AS scr,
COUNT (8) cnt
FROM DEV.CONCEPT_RELATIONSHIP d
WHERE EXISTS
(SELECT 1
FROM DEV.CONCEPT c
WHERE c.VOCABULARY_ID = 32 AND c.CONCEPT_ID = CONCEPT_ID_1)
AND EXISTS
(SELECT 1
FROM DEV.CONCEPT c
WHERE c.VOCABULARY_ID = 32 AND c.CONCEPT_ID = CONCEPT_ID_2)
AND NVL(d.INVALID_REASON, 'X') <> 'D'
AND NOT EXISTS
(SELECT 1
FROM CONCEPT_RELATIONSHIP_STAGE c
WHERE c.CONCEPT_ID_1 = d.CONCEPT_ID_1
AND c.CONCEPT_ID_2 = d.CONCEPT_ID_2
AND c.RELATIONSHIP_ID = d.RELATIONSHIP_ID);

Current Result:

- Num Rec in stage 1050
- Num Rec in DEV not deleted                 0
- How many records would be new in DEV added               66
- How many DEV active will be marked for deletion          0

1.5.6 Load new concept relationships into DEV schema,mark deprecated concept relatuionships as deleted

Transfer records from CONCEPT_RELATIONSHIP_STAGE to DEV.CONCEPT_RELATIONSHIP table

$ sqlplus VACLASS_20120806/myPass@DEV_VOCAB @32_load_relations.sql